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簡(jiǎn)要描述：Fluoxetine hydrochloride 56296-78-7描述Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
產(chǎn)品型號(hào)：abs47027075廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-11-25訪 問(wèn) 量：969產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 56296-78-7 |
|---|---|---|---|
| 分子式 | C17H18F3NO.HCl | 純度 | 99% |
| 分子量 | 345.79 | 貨號(hào) | abs47027075 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an antidepressant of the selective se | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Fluoxetine hydrochloride 56296-78-7
| 產(chǎn)品描述 | |
| 描述 | Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 鹽酸氟xi??；LY-110140 |
| 外觀 | 白色或類白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 34.6 mg/mL (100 mM) water : 3.5 mg/mL (10 mM) |
| 生物活性 | |
| 靶點(diǎn) | 5-HT |
| In vitro(體外研究) | Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. |
| In vivo(體內(nèi)研究) | Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ((ex)) and norepinephrine ((ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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