Flutamide 13311-84-7

簡要描述：Flutamide 13311-84-7
描述
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor.

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品牌	absin	CAS	13311-84-7
分子式	C11H11F3N2O3	純度	＞98%
分子量	276.21	貨號	abs47027092
規(guī)格	50mg	供貨周期	現(xiàn)貨
主要用途	an antiandrogen drug	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Flutamide 13311-84-7

產(chǎn)品描述
描述	Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	氟ta胺；SCH 13521
外觀	淡黃色結(jié)晶性粉末
可溶性/溶解性	DMSO : 51 mg/mL (184.6 mM) Ethanol : 51 mg/mL (184.6 mM)
生物活性
靶點(diǎn)	Androgen Receptor
In vitro(體外研究)	Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.
In vivo(體內(nèi)研究)	Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.
參考文獻(xiàn)
參考文獻(xiàn)	1. Chang HC, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11173-7. 2. Pazos F, et al. Pediatr Res. 2000 Jul;48(1):96-103. 3. Shilling AD, Williams DE. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):187-94.

研究領(lǐng)域
研究領(lǐng)域	CancerSignal transductionNuclear signalingNuclear hormone receptorsOther Developmental BiologyReproductionHormones EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsTestosterone NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsTestosterone Drug DiscoverySmall Molecule DrugLead Compound Discovery

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