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簡要描述：Methacycline hydrochlorid 3963-95-9儲存/保存方法Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
產(chǎn)品型號：abs47027107廠商性質(zhì)：生產(chǎn)廠家更新時間：2025-11-26訪 問 量：840產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 3963-95-9 |
|---|---|---|---|
| 分子式 | C22H23ClN2O8 | 純度 | ＞98% |
| 分子量 | 478.88 | 貨號 | abs47027107 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used to treat various infections. | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Methacycline hydrochlorid 3963-95-9
| 產(chǎn)品描述 | |
| 描述 | Methacycline hydrochloride is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 鹽suan美他環(huán)素；鹽酸甲烯tu霉素 |
| 外觀 | 黃色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 3 mg/mL (6.26 mM) Water : 5 mg/mL (10.44 mM) |
| 生物活性 | |
| 靶點 | protein synthesis |
| In vitro(體外研究) | Methacycline inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline inhibits TGF-β1-induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1. |
| In vivo(體內(nèi)研究) | Methacycline (100 mg/kg, i.p.) delivered daily beginning 10 days after intratracheal bleomycin improves survival at Day 17. Methacycline attenuates Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA. Methacycline does not attenuate inflammatory cell accumulation or alter TGF-β1-responsive genes in alveolar macrophages. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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