Risedronate Sodium 115436-72-1

簡(jiǎn)要描述：Risedronate Sodium 115436-72-1
a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.

產(chǎn)品型號(hào)：abs47027462
廠商性質(zhì)：生產(chǎn)廠家
更新時(shí)間：2025-12-12
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品牌	absin	CAS	115436-72-1
分子式	C7H10NO7P2 ? Na	純度	99%
分子量	305.09	貨號(hào)	abs47027462
規(guī)格	25mg	供貨周期	現(xiàn)貨
主要用途	used in the treatment of osteoporosis	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Risedronate Sodium 115436-72-1

產(chǎn)品描述
描述	Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.
純度	99%
儲(chǔ)存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	利sai膦酸鈉；Risedronic Acid Sodium
外觀	白色或類白色結(jié)晶性粉末
可溶性/溶解性	water : 3.1 mg/mL (10 mM)
生物活性
靶點(diǎn)	FPS,HAP
In vitro(體外研究)	Risedronate causes a total inhibition of colony formation whereas Etidronate has relatively little effect in calcifying fibroblastic colony-forming unit (CFU-f) cultures of rat bone marrow cells in vitro. Risedronate (1 μM) decreases the formation of colonies displaying osteoblastic characteristics such as alkaline phosphatase expression, collagen accumulation, and calcification. Risedronate (1 nM) and alendronate increases the formation of fibroblastic colonies, suggesting a mild anabolic effect, however, the formation of colonies with osteoblastic properties is not affected. Risedronate significantly inhibits expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 induced by RANKL in bone marrow-derived macrophages (BMMs).
In vivo(體內(nèi)研究)	Risedronate (1 mg/kg) significantly increases the volumetric densities of bone (Vb) and osteoblast Vob and decreases Vm more prominently in rats. Risedronate causes a significant and dose-dependent reduction of tooth movement after the orthodontic force is applied in rats. Risedronate prevents a reduction in periosteal bone formation and an increase in endocortical bone erosion, resulting in prevention of alterations in percent cortical bone and marrow areas. Risedronate increases osteocyte density and lacunar occupancy and prevented a GC-induced increase in cortical porosity. Risedronate and Vitamin K(2) has additive effects on osteocyte density and lacunar occupancy and a synergistic effect on cortical porosity.
參考文獻(xiàn)
參考文獻(xiàn)	1. Bergstrom JD, et al. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. 2. Jahnke W, Henry C. ChemMedChem. 2010 May 3;5(5):770-6. 3. Coxon FP, et al. Bone. 2005 Sep;37(3):349-58. 4. Nancollas GH, et al. Bone. 2006 May;38(5):617-27. 5. Dunford JE, et al. J Pharmacol Exp Ther. 2001 Feb; 296(2):235-42.

研究領(lǐng)域
研究領(lǐng)域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Risedronate Sodium 115436-72-1溫馨提示：本產(chǎn)品僅作科研實(shí)驗(yàn)使用，不支持臨床等研究

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Risedronate Sodium 115436-72-1

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