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簡(jiǎn)要描述：Noradrenaline bitartrate monohydrate 108341-18-0Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
產(chǎn)品型號(hào)：abs47027473廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-15訪 問 量：707產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 108341-18-0 |
|---|---|---|---|
| 分子式 | C8H11NO3.C4H6O6.H2O | 純度 | 99% |
| 分子量 | 337.28 | 貨號(hào) | abs47027473 |
| 規(guī)格 | 500mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a direct alpha-adrenergic receptors s | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Noradrenaline bitartrate monohydrate 108341-18-0
| 產(chǎn)品描述 | |
| 描述 | Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 酒石酸去jia腎上腺素；Noradrenaline bitartrate monohydrate |
| 外觀 | 白色或類白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 31.9 mg/mL (100 mM) water : 31.9 mg/mL (100 mM) |
| 生物活性 | |
| 靶點(diǎn) | Adrenergic Receptor |
| In vitro(體外研究) | Norepinephrine(NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Cardiovascular NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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