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簡要描述：Sparfloxacin 110871-86-8Sparfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections.
產(chǎn)品型號：abs47027494廠商性質(zhì)：生產(chǎn)廠家更新時間：2025-12-16訪 問 量：754產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 110871-86-8 |
|---|---|---|---|
| 分子式 | C19H22F2N4O3 | 純度 | 99% |
| 分子量 | 392.4 | 貨號 | abs47027494 |
| 規(guī)格 | 100mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used in the treatment of bacterial infec | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Sparfloxacin 110871-86-8
| 產(chǎn)品描述 | |
| 描述 | Sparfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. |
| 純度 | 99% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 司帕sha星 |
| 外觀 | 黃色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 9 mg/mL (22.93 mM) |
| 生物活性 | |
| In vitro(體外研究) | Sparfloxacin shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella . Sparfloxacin targets DNA gyrase and inhibits DNA synthesis. |
| In vivo(體內(nèi)研究) | Sparfloxacin showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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