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簡(jiǎn)要描述：Oxolinic acid 14698-29-4Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.
產(chǎn)品型號(hào)：abs47027571a廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-18訪 問(wèn) 量：738產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 14698-29-4 |
|---|---|---|---|
| 分子式 | C13H11NO5 | 純度 | 98% |
| 分子量 | 261.24 | 貨號(hào) | abs47027571 |
| 規(guī)格 | 500mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent inhibitor of DNA gyrase | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Oxolinic acid 14698-29-4
| 產(chǎn)品描述 | |
| 描述 | Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 惡喹酸 |
| 外觀 | 白色至類(lèi)白色固體 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點(diǎn) | bacterial DNA gyrase,DNA synthesis,dopamine uptake |
| In vitro(體外研究) | Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml. |
| In vivo(體內(nèi)研究) | The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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