Triethylenethiophosphoramide 52-24-4

簡要描述：Triethylenethiophosphoramide 52-24-4
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.

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品牌	absin	CAS	52-24-4
分子式	C6H12N3PS	純度	＞98%
分子量	189.22	貨號	abs47027584
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a polyfunctional	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Triethylenethiophosphoramide 52-24-4

產(chǎn)品描述
描述	Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	三亞乙基硫代磷酰胺；Thio-TEPA
外觀	white solid
可溶性/溶解性	DMSO : 91 mg/mL (480.9 mM)
生物活性
靶點	DNA Alkylator_Crosslinker
In vitro(體外研究)	Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM.
In vivo(體內(nèi)研究)	Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice.

研究領(lǐng)域
研究領(lǐng)域	CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

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