Cisapride 81098-60-4

簡要描述：Cisapride 81098-60-4
Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine

產(chǎn)品型號：abs47027605
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-12-22
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詳細介紹

品牌	absin	CAS	81098-60-4
分子式	C23H29ClFN3O4	純度	＞98%
分子量	465.95	貨號	abs47027605
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a serotonin type 4 (5-HT4) receptor a	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Cisapride 81098-60-4

產(chǎn)品描述
描述	Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	西sha必利；R 51619；(±)-Cisaprid
外觀	白色固體
可溶性/溶解性	10 mM in DMSO
生物活性
靶點	hERG channel ,5-HT4 receptor
In vitro(體外研究)	Cisapride is a 5-HT4 receptor agonist, also a hERG blockers. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist.
參考文獻
參考文獻	1. Nagakura Y, et al. Pharmacol Res. 1999 May;39(5):375-82. 2. Walker BD, et al. Br J Pharmacol. 1999 Sep;128(2):444-50. 3. Rahme MM, et al. Circulation. 1999 Nov 9;100(19):2010-7. 4. Chen J, et al. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12461-6. 5. Haga N, et al. Neurogastroenterol Motil. 1998 Aug;10(4):295-303.

研究領(lǐng)域
研究領(lǐng)域	MetabolismTypes of diseaseObesity NeuroscienceProcesses NeuroscienceNeurology processMetabolism NeuroscienceNeurotransmissionReceptors / ChannelsGPCRSerotonin Receptors Signal TransductionSignaling PathwayG Protein SignalingGPCR Drug DiscoverySmall Molecule DrugLead Compound Discovery

Cisapride 81098-60-4溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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Cisapride 81098-60-4

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