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18438616290
簡(jiǎn)要描述：Fluconazole 86386-73-4Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
產(chǎn)品型號(hào)：abs47027676廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-24訪 問(wèn) 量：560產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 86386-73-4 |
|---|---|---|---|
| 分子式 | C13H12F2N6O | 純度 | ＞98% |
| 分子量 | 306.27 | 貨號(hào) | abs47027676 |
| 規(guī)格 | 500mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used to treat oropharyngeal candidiasis | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Fluconazole 86386-73-4
| 產(chǎn)品描述 | |
| 描述 | Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 氟kang唑; UK-49858 |
| 外觀 | White to Off-White Solid |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (326.51 mM) |
| 生物活性 | |
| 靶點(diǎn) | lanosterol 14 alpha-demethylase |
| In vitro(體外研究) | Fluconazole in combination with amphotericin B (AmB) has a synergistic effect on C. albicans planktonic cells but does not alter AmB activity against biofilms. Fluconazole and caspofungin have an antagonistic effect against biofilms but not with planktonic cells. Fluconazole-mediated membrane perturbation (due to inhibition of ergosterol biosynthesis) increases calcineurin inhibitor intracellular concentrations. Fluconazole treatment significantly reduces levels of ergosterol within the cell in C. albicans planktonic cells, leading to cell membrane perturbation. Fluconazole activity is less sensitive to acidic medium than is that of ketoconazole. Fluconazole is approximately 16-fold less active than ketoconazole against 35 representative isolates of C. albicans at physiologic pH. Fluvastatin, a cholesterol-lowering drug, exhibits minimal activity (MICs of 64 to >128 mg/mL) against Candida species and Cryptococcus neoformans. Fluconazole combined with itraconazole exhibits potent activities against C. albicans, C. tropicalis, C. parapsilosis, and C. neoformans, including flucon- azole-resistant strains of C. albicans and C. tropicalis. |
| In vivo(體內(nèi)研究) | Fluconazole is very effective in prolonging survival of rats infected with a representative candidal strain. Fluconazole has a dramatic effect on the fungicidal activity of flucytosine in murine cryptococcal meningitis. Fluconazole combined with flucytosine and amphotericin B have significantly improved activity against cryptococcal meningitis compared with the activity of each drug used alone. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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