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簡(jiǎn)要描述：Deferasirox 201530-41-8Deferasirox is an oral iron chelator.
產(chǎn)品型號(hào)：abs47027705廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-25訪 問(wèn) 量：578產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 201530-41-8 |
|---|---|---|---|
| 分子式 | C21H15N3O4 | 純度 | 99% |
| 分子量 | 373.36 | 貨號(hào) | abs47027705 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | use is to reduce chronic iron overload | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Deferasirox 201530-41-8
| 產(chǎn)品描述 | |
| 描述 | Deferasirox is an oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. It is the first oral medication approved in the USA for this purpose. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 地拉羅司；ICL 670 |
| 外觀 | 白色至淡黃色性粉末 |
| 可溶性/溶解性 | DMSO : 69 mg/mL (184.8 mM) Ethanol : 2 mg/mL (5.35 mM) |
| 生物活性 | |
| 靶點(diǎn) | iron |
| In vitro(體外研究) | In LX-2 cells treated with 50?μM deferasirox for 12?h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120?h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner. |
| In vivo(體內(nèi)研究) | The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer Metabolism CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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