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簡(jiǎn)要描述：Aliskiren hemifumarate 173334-58-2Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
產(chǎn)品型號(hào)：abs47027738廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-26訪 問 量：679產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 173334-58-2 |
|---|---|---|---|
| 分子式 | C30H53N3O6.1/2C4H4O4 | 純度 | 96% |
| 分子量 | 1219.6 | 貨號(hào) | abs47027738 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a direct renin inhibitor | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Aliskiren hemifumarate 173334-58-2
| 產(chǎn)品描述 | |
| 描述 | Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM. |
| 純度 | 96% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | Soluble in DMSO |
| 生物活性 | |
| 靶點(diǎn) | Renin |
| In vitro(體外研究) | Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans. |
| In vivo(體內(nèi)研究) | Aliskiren hemifumarate ( Once-daily oral treatment with Aliskiren hemifumarate lowers blood pressure effectively, with a safety and tolerability profile, in patients with mild-to-moderate hypertension. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CardiovascularBloodBlood Pressure regulation CardiovascularBloodOther MetabolismPathways and ProcessesCofactors, Vitamins / mineralsVitamins / minerals NeuroscienceProcesses Signal TransductionMetabolismVitamins / Minerals Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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