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簡要描述：Isotretinoin 4759-48-2Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.
產品型號：abs47027783廠商性質：生產廠家更新時間：2025-12-30訪 問 量：612產品分類
Product Category詳細介紹
| 品牌 | absin | CAS | 上海 |
|---|---|---|---|
| 分子式 | C20H28O2 | 純度 | 98% |
| 分子量 | 300.44 | 貨號 | abs47027783 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used as a chemotherapy medication | 應用領域 | 化工,生物產業(yè),農林牧漁,制藥/生物制藥,綜合 |
Isotretinoin 4759-48-2
| 產品描述 | |
| 描述 | Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 13-cis-Retinoic acid；異維Asuan；13-順-視黃suan |
| 外觀 | 黃色或者類橙色結晶性粉末 |
| 可溶性/溶解性 | DMSO : 60 mg/mL (199.7 mM) Ethanol : 1 mg/mL (3.32 mM), warmed |
| 生物活性 | |
| 靶點 | hydroxylase |
| In vitro(體外研究) | Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. |
| In vivo(體內研究) | Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. |
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| 研究領域 | |
| 研究領域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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