Doxycycline 564-25-0

簡(jiǎn)要描述：Doxycycline 564-25-0
Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity.

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品牌	absin	CAS	564-25-0
分子式	C22H24N2O8	純度	≥98%
分子量	444.44	貨號(hào)	abs47027821
規(guī)格	5mg	供貨周期	現(xiàn)貨
主要用途	is a synthetic tetracycline derivative	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Doxycycline 564-25-0

產(chǎn)品描述
描述	Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity.
純度	≥98%
儲(chǔ)存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	多xi環(huán)素
外觀	Light yellow powder
可溶性/溶解性	Water:630 mg/L
生物活性
In vitro(體外研究)	100 ng/mL-5 µg/mL Dox can significantly alter the metabolic profile of the cell, as well as reduce the proliferative rate, though the effect size depends upon the particular cell line used. Doxycycline arrests cells in G1-S phase of the cell cycle in PANC-1 cells and induces the expression of p53 and its downstream target p21. It down-regulates antiapoptotic genes and induces proapoptotic genes. Doxycycline also induces apoptosis through a Fas/Fas-ligand dependent pathway in Jurkat T lymphocytes.
In vivo(體內(nèi)研究)	Doxycycline successfully reduces tumor growth in vivo (inhibited pancreatic cancer cell growth).
參考文獻(xiàn)
參考文獻(xiàn)	1. Griffin MO, et al. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. 2. Preissner S, et al. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. 3. Babu E, et al. Jpn J Pharmacol. 2002 Jan;88(1):69-76. 4. Pringle M, et al. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. 5. Kumar S, et al. J Clin Microbiol. 2007 Feb;45(2):392-4.

研究領(lǐng)域
研究領(lǐng)域	CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

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