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簡(jiǎn)要描述：AF 353 865305-30-2AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
產(chǎn)品型號(hào)：abs47027899廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-06訪 問(wèn) 量：723產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 865305-30-2 |
|---|---|---|---|
| 分子式 | C14H17IN4O2 | 純度 | 98% |
| 分子量 | 400.21 | 貨號(hào) | abs47027899 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a novel, potent | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
AF 353 865305-30-2
| 產(chǎn)品描述 | |
| 描述 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | AF 353；Ro-4 |
| 可溶性/溶解性 | DMSO : 100 mg/mL (249.87 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | P2X3 |
| In vitro(體外研究) | AF-353 (Ro-4) is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. AF-353 (Ro-4) also blocks human P2X2/3 channel function with marginally reduced potency with a p50 of 7.3. |
| In vivo(體內(nèi)研究) | AF-353 (Ro-4) does not compromise oxygen levels or cardiac function. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer MetabolismResponse to hypoxia MetabolismPathways and ProcessesMetabolism processesHypoxia NeuroscienceProcesses NeuroscienceNeurotransmissionReceptors / ChannelsLigand-Gated Ion ChannelsP2X Receptors Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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