SD-208 627536-09-8

簡要描述：SD-208 627536-09-8
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.

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品牌	absin	CAS	627536-09-8
分子式	C17H10ClFN6	純度	＞98%
分子量	352.75	貨號	abs47027906
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a selective TGF-βRI (ALK5) inhibitor	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

SD-208 627536-09-8

產(chǎn)品描述
描述	SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	SD 208；SD208；TGF-β RI Kinase Inhibitor V
外觀	off-white to tan solid
可溶性/溶解性	DMSO : 7.1 mg/mL (20 mM), with gentle warming
生物活性
靶點	TGF-βRI (ALK5)
In vitro(體外研究)	SD-208 inhibits the cell growth and constitutive and TGF-beta-evoked migration and invasion, and enhances immunogenicity in murine SMA-560 and human LN-308 glioma cells. SD-208 blocka TGF-beta-induced phosphorylation of the receptor-associated Smads, Smad2 and Smad3, and stimulates epithelial-to-mesenchymal transdifferentiation, migration, and invasiveness into Matrigel in vitro. SD-208 also abolishes the promoting effect of TGF-β on neointimal smooth muscle-like cell (SMLC) proliferation and migration in vitro.
In vivo(體內(nèi)研究)	SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA).
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研究領(lǐng)域
研究領(lǐng)域	CancerCancer Metabolism CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery

SD-208 627536-09-8溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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