2,3-Butanedione 2-Monoxime 57-71-6

簡要描述：2,3-Butanedione 2-Monoxime 57-71-6
2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction.

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品牌	absin	CAS	57-71-6
分子式	C25H52NO4P	純度	＞99%
分子量	461.66	貨號	abs47027927
規(guī)格	25mg	供貨周期	現(xiàn)貨
主要用途	is an inhibitor of skeletal	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

2,3-Butanedione 2-Monoxime 57-71-6

產(chǎn)品描述
描述	2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction.
純度	＞99%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	2,3-丁烷二酮一肟；二乙酰一肟；NSC 660；NSC 116103
外觀	白色至類白色結(jié)晶性粉末
可溶性/溶解性	10 mM in DMSO
生物活性
靶點(diǎn)	skeletal muscle myosin-II
In vitro(體外研究)	BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels.
In vivo(體內(nèi)研究)	BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation.
參考文獻(xiàn)
參考文獻(xiàn)	1. Vyomesh Patel, et al. Cancer Res, 2002, 62(5), 1401-1409 2. Momota H, et al. Cancer Res, 2005, 65(16), 7429-7435.

研究領(lǐng)域
研究領(lǐng)域	Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery

2,3-Butanedione 2-Monoxime 57-71-6溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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