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簡(jiǎn)要描述：Cariporide 159138-80-4Cariporide (HOE-642), a potent NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets
產(chǎn)品型號(hào)：abs47027959廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-08訪 問(wèn) 量：553產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 159138-80-4 |
|---|---|---|---|
| 分子式 | C12H17N3O3S | 純度 | 99% |
| 分子量 | 283.3467 | 貨號(hào) | abs47027959 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | inhibitory effects on the degranulation | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Cariporide 159138-80-4
| 產(chǎn)品描述 | |
| 描述 | Cariporide (HOE-642), a potent NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1). |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | Soluble in DMSO |
| 生物活性 | |
| 靶點(diǎn) | Sodium Channel |
| In vitro(體外研究) | Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1). |
| In vivo(體內(nèi)研究) | Intravenous administration of cariporide significantly decreases brain Na+ uptake and reduces cerebral edema, brain swelling, and infarct volume. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Cardiovascular Immunology CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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