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簡要描述：BLU9931 1538604-68-0BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM).
產(chǎn)品型號：abs47028005廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-12訪 問 量：594產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1538604-68-0 |
|---|---|---|---|
| 分子式 | C26H22Cl2N4O3 | 純度 | 98% |
| 分子量 | 509.38 | 貨號 | abs47028005 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is the first selective small molecule in | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
BLU9931 1538604-68-0
| 產(chǎn)品描述 | |
| 描述 | BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM). |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點(diǎn) | FGFR4 ,FGFR3 |
| In vitro(體外研究) | In MDA-MB-453 cells, BLU9931 potently inhibits phosphorylation of FGFR4 signaling pathway. BLU9931 inhibits proliferation of HCC cell lines that express an intact FGFR4 signaling complex, such as Hep 3B, HUH-7, and JHH-7 cell lines, with EC50 of |
| In vivo(體內(nèi)研究) | In mice bearing the FGF19-amplified Hep 3B liver tumors, BLU9931 (300 mg/kg, p.o.) leads to tumor regression and prevents this weight loss induced by tumors. In mice bearing the FGF19-overexpressing PDX-derived LIXC012 xenografts, treatment with BLU9931 (300 mg/kg, p.o.) also leads to tumor regression. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerGrowth factorsFGF CardiovascularAngiogenesisGrowth FactorsFGFFGF Receptors MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceCell Type MarkerNeural Stem Cell marker Signal TransductionGrowth Factors/HormonesFGF Stem CellsNeural Stem CellsSurface Molecules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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