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簡要描述：LY-2874455 1254473-64-7LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 o
產(chǎn)品型號：abs47028010廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-13訪 問 量：647產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1254473-64-7 |
|---|---|---|---|
| 分子式 | C21H19Cl2N5O2 | 純度 | 98% |
| 分子量 | 444.31 | 貨號 | abs47028010 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a pan-FGFR inhibitor | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
LY-2874455 1254473-64-7
| 產(chǎn)品描述 | |
| 描述 | LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 100 mM in DMSO and ethanol |
| 生物活性 | |
| 靶點(diǎn) | FGFR2 ,FGFR1 ,FGFR4 ,FGFR3 ,VEGFR2 |
| In vitro(體外研究) | In RT-112 cells, HUVECs, KATO-III cells, and SNU-16 cells, LY2874455 inhibits FGF/FGFR-mediated signaling activities. LY2874455 shows FGFR-dependent antiproliferative effects in KMS-11, OPM-2, SNU-16 and KATO-III cells. |
| In vivo(體內(nèi)研究) | LY2874455 exhibits a potent inhibition of FGF-induced Erk phosphorylation in the heart tissues of mice with TED50 and TED90 values of 1.3 and 3.2 mg/kg, respectively. In mice bearing RT-112, OPM-2 (DSMZ), SNU-16, or NCI-H460 xenograft, LY2874455 (3 mg/kg p.o.) results in dose-dependent inhibition of the tumor growth. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerGrowth factorsFGF CancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinases CardiovascularAngiogenesisGrowth FactorsFGFFGF Receptors Developmental BiologyLineage specificationEctoderm NeuroscienceDevelopment NeuroscienceNeurology processNeurogenesis Signal TransductionGrowth Factors/HormonesFGF Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Stem CellsLineage MarkersEctoderm Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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