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簡要描述：Vipadenant 442908-10-3Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
產(chǎn)品型號(hào)：abs47028016廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-13訪 問 量：759產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 442908-10-3 |
|---|---|---|---|
| 分子式 | C16H15N7O | 純度 | 98% |
| 分子量 | 321.34 | 貨號(hào) | abs47028016 |
| 規(guī)格 | 1mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an adenosine A2a antagonist | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Vipadenant 442908-10-3
| 產(chǎn)品描述 | |
| 描述 | Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM). |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點(diǎn) | Adenosine Receptor |
| In vivo(體內(nèi)研究) | Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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