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簡(jiǎn)要描述：GS-7340 Tenofovir alafenamide 379270-37-8Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
產(chǎn)品型號(hào)：abs47028038廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-14訪 問(wèn) 量：625產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 379270-37-8 |
|---|---|---|---|
| 分子式 | C21H29N6O5P | 純度 | 99% |
| 分子量 | 476.47 | 貨號(hào) | abs47028038 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used to treat HIV and Hepatitis B. | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
GS-7340 Tenofovir alafenamide 379270-37-8
| 產(chǎn)品描述 | |
| 描述 | Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | Soluble in DMSO |
| 生物活性 | |
| 靶點(diǎn) | Reverse transcriptase |
| In vitro(體外研究) | GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. |
| In vivo(體內(nèi)研究) | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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