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簡(jiǎn)要描述：PHOB 1429651-50-2HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs.
產(chǎn)品型號(hào)：abs47028043廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-14訪 問(wèn) 量：664產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1429651-50-2 |
|---|---|---|---|
| 分子式 | C17H18N2O4 | 純度 | ＞98% |
| 分子量 | 314.34 | 貨號(hào) | abs47028043 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent, selective HDAC6 inhibitor | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
PHOB 1429651-50-2
| 產(chǎn)品描述 | |
| 描述 | HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外觀 | white to beige powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (159.06 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | HDAC6,HDAC3,HDAC8,HDAC1,HDAC10 |
| In vitro(體外研究) | In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells. |
| In vivo(體內(nèi)研究) | In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass II / Hda1 Class Stem CellsSignaling PathwaysWntHDACs Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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