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簡(jiǎn)要描述：C646 328968-36-1C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases.
產(chǎn)品型號(hào)：abs47028050廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-14訪 問(wèn) 量：703產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 328968-36-1 |
|---|---|---|---|
| 分子式 | C24H19N3O6 | 純度 | 98% |
| 分子量 | 445.42 | 貨號(hào) | abs47028050 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an inhibitor for histone acetyltrans | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
C646 328968-36-1
| 產(chǎn)品描述 | |
| 描述 | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | C 646 |
| 外觀 | red to brown powder |
| 可溶性/溶解性 | DMSO : 11.1 mg/mL (25 mM) |
| 生物活性 | |
| 靶點(diǎn) | p300/CBP |
| In vitro(體外研究) | C646 is an inhibitor for histone acetyltransferase, inhibits p300 with a Ki of 400 nM and is selective versus other acetyltransferases. C646 produces 86% inhibition of p300 in vitro at 10 μM. C646 is a classical reversible p300 inhibitor. C646 treatment (25μM) reduces histone H3 and H4 acetylation levels and abrogates TSA-induced acetylation in cells. C646 (20μM) induces apoptosis in androgen-sensitive and castration-resistant prostate cancer cell lines by interfering with AR and NF-kB pathways. C646 blocks dynamic acetylation of H3K4me3 globally in mouse and fly cells, and locally across the promoter and start-site of inducible genes in the mouse, thereby disrupting RNA polymerase II association and the activation of these genes. |
| In vivo(體內(nèi)研究) | C646 infused into the ILPFC immediately after weak extinction training enhances the consolidation of fear extinction memory. C646 attenuates mechanical allodynia and thermal hyperalgesia, accompanied by a suppressed COX-2 expression, in the spinal cord. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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