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簡要描述：Ascomycin (FK520) 104987-12-4；11011-38-4Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
產(chǎn)品型號：abs47028058廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-01-15訪 問 量：542產(chǎn)品分類
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| 品牌 | absin | CAS | 104987-12-4；11011-38-4 |
|---|---|---|---|
| 分子式 | C43H69NO12 | 純度 | ＞98% |
| 分子量 | 792.01 | 貨號 | abs47028058 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a neutral macrolide immunosuppressant | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Ascomycin (FK520) 104987-12-4；11011-38-4
| 產(chǎn)品描述 | |
| 描述 | Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 長川霉素；子囊霉素；Immunomycin；FR-900520；FK520 |
| 外觀 | 白色至類白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 39.6 mg/mL (50 mM) Ethanol : 39.6 mg/mL (50 mM) |
| 生物活性 | |
| 靶點 | calcineurin phosphatase |
| In vitro(體外研究) | Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein. |
| In vivo(體內(nèi)研究) | Ascomycin (3.2 mg/kg, i.m.) clearly prolongs skin allograft survival in rats. Ascomycin, at 50 or 100 μM, produces anticonvulsant effect against picrotoxin-induced seizures when infused into the rat hippocampus. |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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