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簡要描述：MI-2 (Menin-MLL Inhibitor) 1271738-62-5MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
產(chǎn)品型號：abs47028120廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-19訪 問 量：611產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1271738-62-5 |
|---|---|---|---|
| 分子式 | C18H25N5S2 | 純度 | ＞98% |
| 分子量 | 375.55 | 貨號 | abs47028120 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent menin-MLL interaction inhibi | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
MI-2 (Menin-MLL Inhibitor) 1271738-62-5
| 產(chǎn)品描述 | |
| 描述 | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Menin-MLL inhibitor 2；MI 2；MI2 |
| 外觀 | Light yellow to yellow solid |
| 可溶性/溶解性 | DMSO : 70 mg/mL (186.4 mM) Ethanol : 70 mg/mL (186.4 mM) |
| 生物活性 | |
| 靶點(diǎn) | Menin-MLL interaction |
| In vitro(體外研究) | In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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