GO-6983

簡要描述：GO-6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.

產(chǎn)品型號：abs810742
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-11-11
訪問量：1136

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生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質(zhì)組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

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詳細介紹

品牌	absin	CAS	133053-19-7
分子式	C26H26N4O3	純度	442.51
分子量	>98%	貨號	abs810742
規(guī)格	2mg	供貨周期	現(xiàn)貨
主要用途	PKCγ ,PKCα ,PKCβ ,PKCδ ,PKCζ	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

產(chǎn)品描述
描述	GO-6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.
純度	>98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	Go 6983；Go6983
外觀	red powder
可溶性/溶解性	DMSO : ≥ 34 mg/mL (76.83 mM)
生物活性
靶點	PKCγ ,PKCα ,PKCβ ,PKCδ ,PKCζ
In vitro(體外研究)	GO-6983 (300 μM) suppresses PKCμ auto-phosphorylation by 20% reduction in NIH3T3 transfected with PKCμ. In hearts reperfused with PMNs and G? 6983 (100 nM), left ventricular developed pressure (LVDP) and the rate of LVDP recoveres to 89% and 74% of baseline values, respectively, significantly higher than PMNs alone. G? 6983 (100 nM) significantly reduces PMNs adherence to the endothelium and infiltration into the myocardium compared with Ischemia followed by reperfusion (I/R)+ PMN hearts, and significantly inhibits superoxide release from PMNs by 90%. G? 6983 attenuates post-I/R cardiac contractile dysfunction in the presence of PMNs, which may be related in part to decreased superoxide production. G? 6983 significantly inhibits antigen-induced superoxide release from leukocytes of patients previously sensitized to tree pollen. Go 6983 inhibited intracellular Ca(2+) accumulation in human vascular tissue, suggesting a mechanism for its vasodilator properties. Go-6983 (1 μM) combined with Ro-31-8425 (390 nM) slightly inhibits Angiotensin II–induced PLD2 activity in PGSMCs. Go 6983 is isoform-specific PKC inhibitor that target the ATP binding site. Go 6983 inhibits ΔPfPKB activity with an IC50 of 1 μM. In Go 6983 (5 μM)-treated cells, the number of rings in the following cycle is markedly less compared with the control cultures. Go 6983 (5 μM) treatment results in an almost 60% decrease in formation of new rings in P. falciparum cultures.
In vivo(體內(nèi)研究)	Go6983 (22.0 μg/mouse, i.v.) strongly inhibits tumor metastasis by 51.2 % in a mouse pulmonary B16BL6 tumor model.

研究領域
研究領域	CardiovascularHeartHypertrophyOther NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionProtein PhosphorylationSer / Thr KinasesPKC Drug DiscoverySmall Molecule DrugLead Compound Discovery

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GO-6983

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