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簡要描述：U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM).
產(chǎn)品型號：abs810003廠商性質(zhì)：生產(chǎn)廠家更新時間：2025-10-30訪 問 量：1575產(chǎn)品分類
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| 品牌 | absin | CAS | 109511-58-2 |
|---|---|---|---|
| 分子式 | C18H16N6S2 | 純度 | >98% |
| 分子量 | 380.48 | 貨號 | abs810003 |
| 規(guī)格 | 5mg;10mg;25mg;50mg;100mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a selective MAP Kinase Kinase inhibit | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 產(chǎn)品描述 | |
| 描述 | U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | U0126；U 0126 |
| 外觀 | Lyophilized powder |
| 可溶性/溶解性 | Soluble in DMSO at 200 mg/mL |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerSignal transductionProtein phosphorylationSerine/threonine kinasesMAPK pathway Signal TransductionProtein PhosphorylationSer / Thr KinasesMAPK Pathway Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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