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18438616290
簡(jiǎn)要描述：Recombinant Mouse IL-4 Protein:Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.
產(chǎn)品型號(hào)：abs04697廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-10-30訪 問(wèn) 量：1254產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | 貨號(hào) | abs04697 |
|---|---|---|---|
| 規(guī)格 | 10ug;50ug;100ug | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | produced by our E.coli expression syste | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Recombinant Mouse IL-4 Protein
| 概述 | |
| 描述 | Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed. |
| 別名 | IL-4蛋白;Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1 |
| 種屬 | Mouse |
| 來(lái)源 | E.coli |
| 形態(tài) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 5% Trehalose, pH 6.5. |
| 性能 | |
| 標(biāo)簽 | No Tag |
| 純度 | Greater than 95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素水平 | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
| 活性 | Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells. The ED50 for this effect is 0.01 ng/mL. |
| 溶解方法 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 儲(chǔ)存/保存方法 | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| 靶標(biāo) | |
| 背景說(shuō)明 | Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α-helix structure. IL-4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL-4 is primarily expressed by Th2-biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by na?ve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. |
| Accession | P07750 |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) | 1、A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B cells. Wang Z. et al. J Virol. 2017. 2、AID Recognizes Structured DNA for Class Switch Recombination. Qi Qiao. et al. Molecular Cell. 2017. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerTumor immunologyCytokinesInterleukins ImmunologyAdaptive ImmunityRegulatory T Cells ImmunologyInnate ImmunityCytokinesInterleukins NeuroscienceProcesses Drug DiscoveryAntibody DrugAntibody Preparation and ScreeningScreening |
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